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Whole Body Autoradiography

WIL Research has established a Radiography and Imaging (R&I) laboratory with state-of-the-art instrumentation and exceptional technical expertise. Our R&I services support discovery, non-clinical and clinical research to meet the regulatory requirements of agencies worldwide in a GLP-compliant environment. WIL has extensive experience in designing and conducting all facets of autoradiography studies including whole body autoradiography and micro-autoradiography. The addition of histological verification of site specific radioactivity provides more accurate quantification, especially for small organs.

Capabilities & Services

• Whole body autoradiography (WBA)
• Quantitative and qualitative analysis
• Tissue distribution studies
• Placental transfer
• Melanin binding
• Discovery (screening)
• Micro-autoradiography
• Large animal organ/tissue autoradiography
• Histological verification of tissues
• Pharmacokinetics
• Dosimetry calculations
• Support ICH guidelines and Japanese MLHW regulations
• GLP compliant

Instrumentation

All instruments and software systems have been validated in accordance with a rigorous facility validation program that meets GLP and Part 11 requirements.

• Vibratome 9800 Large Animal Cryomicrotome
• Vibratome Cryocut One Cryomicrotome
• Instrumedics Macro Tape Transfer System (MTTS)
• Instrumedics Cryo-Jane Tape Transfer System
• Fujifilm BAS-5000 Phosphor Image Scanner
• Raytest AIDA Image Analysis Software

Facilities

Our facility has undergone an extensive validation to ensure proper operation and compliance with GLP requirements.

• State-of-the-Art Radiography and Imaging Laboratory
• Unique design allows for smooth work-flow
• Dedicated dark room for imaging and micro-autoradiography procedures
• Lead shielding boxes for best exposures of the phosphor imaging plates
• Adjacent combustion laboratory for verification of standards
• Licensed by the State of Ohio for radioactive materials
• Hydrogen-3
• Carbon-14
• Phosphorus-32
• Sulfur-35
• Chromium-51
• Manganese-54
• Arsenic-73
• Arsenic-74
• Yttrium-90
• Technetium-99m
• Indium-111
• Iodine-125
• Gadolinium-153
• Lutetium-177
• Rhenium-188