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Non-human Primates

Some may view toxicological assessments in non-human primates (NHP) as the apical studies in drug development. However, despite the obvious phylogenic similarities to humans, NHPs may not always be the best or most representative model for toxicity assessment. A clear scientific rationale based on factors such as expected pharmacological activity and metabolic profile should be judiciously considered before deciding upon an NHP model. Traditionally, they have been applied in the safety assessment of proteins, vaccines, oligonucleotides, and small molecules that produce distinctive effects in primates. An NHP may also serve as a tertiary species when additional research is necessary to delineate or clarify conflicting findings based on other animal studies.

WIL Research has been conducting NHP toxicological research successfully since the late eighties. The interdisciplinary research expertise of the WIL staff in areas such as toxico- and pharmacokinetics, metabolism, cardiovascular pharmacology, neuroscience and general toxicology offer flexibility and varied scientific options to our clients for the conduct of their NHP studies.

Our dedicated NHP facilities provide significant capacity and can accommodate multiple large-scale studies. Access is restricted by keycard-activated locks. Rooms are equipped with ante-rooms that provide for additional separation between studies and an area for gowning prior to entering. Pair housing is standard for studies longer than one month with single-housing still an option if required for scientific reasons.

All this, together with an experienced, enthusiastic staff and an active NHP Enrichment Program Committee provides for an optimal and reliable environment for your NHP research.

Capabilities

Routes of Administration

• Nasogastric, oral and capsule
• Intravenous: bolus and infusion
• Subcutaneous
• Eye: topical
• Inhalation

General Toxicology

• Ascending dose
• Repeated dose
• Subchronic
• Chronic

Safety Pharmacology

• Cardiovascular: telemetry
• CNS: functional observational battery
• Respiratory: blood gas assessment (arterial and capillary)

Metabolism

• Toxico/Pharmaco-kinetic studies
• Radiolabeled studies

Support Operations

• NHP Enrichment Program Committee
• Veterinary staff
• Trained dedicated technical staff
• Bioanalytical and analytical chemistry
• Clinical pathology