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Metabolism

WIL Research has the technical expertise, experience and resources to design and conduct all facets of in vivo metabolism and kinetic studies and supporting in vitro studies using radiolabeled or non-radiolabeled chemicals to meet the regulatory requirements of agencies worldwide in a GLP-compliant environment.

WIL has extensive experience supporting discovery-level and non-clinical pharmaceutical research and pesticide regulatory studies. Standard and custom-designed metabolism and kinetic studies can be conducted in a variety of laboratory, domestic and livestock animal species.

Capabilities & Services

In vivo

• ADME (Absorption, Distribution, Metabolism, and Elimination)
• Pharmacokinetics/Toxicokinetics (Bioanalysis)
• Metabolite identification
• Dermal penetration
• Placental transfer
• Tissue distribution
• Mass balance
• Bioequivalence
• Metabolite analytical methods development (including Whole Body Autoradiography)
• Residue chemistry
• All common routes of exposure

In vitro

• Metabolism
• Biomarker assay development
• ELISA development
• Protein binding
• RIA/EIA
• Metabolite identification

Extensive Experience with:

• Dual-labeled experiments
• Uncommonly used isotopes
• Currently Licensed Isotopes
• Hydrogen-3
• Carbon-14
• Phosphorus-32
• Sulfur-35
• Chromium-51
• Manganese-54
• Arsenic-73
• Arsenic-74
• Yttrium-90
• Technetium-99m
• Indium-111
• Iodine-125
• Gadolinium-153
• Lutetium-177
• Rhenium-188
• Small molecules
• Proteins
• Oligonucleotides
• Antibodies
• Liposomal formulations

Instrumentation

Our instruments are housed in a modern, custom-designed facility.

• Liquid Scintillation Counters
• Gamma Counters
• Biological Material Oxidizers
• HPLC and Radio-HPLC
• Radio-TLC
• LC-MS/MS (quadrupole)
• LC-MS (ion trap)
• GC-MS
• Electrophoresis
• Spectrophometers
• Fluorometers

General

Routes of exposure:

• IV bolus
• IV infusion
• Subcutaneous
• Oral
• Gavage
• capsule
• Dermal
• Topicals
• Patches
• Inhalation
• Nose-only
• Whole body
• Bladder instillation
• Lung instillation

Facilities

• Licensed by the State of Ohio for radioactive materials.
• Over 5,000 sq. ft. of dedicated modern laboratory space
• 2,900 sq. ft. dedicated vivarium
• Dedicated necropsy suite
• Decontamination room
• Metabolism units for separate collection of excreta from laboratory, domestic and livestock species
• Biobubble Isolated Bioclean rooms for rodent studies
• Separate, fully equipped large animal facility for livestock species

Experienced with all standard rodent and non-rodent laboratory animals including NHP.