Inhalation Toxicology
WIL Research possesses full-service inhalation capabilities committed to providing a complete spectrum of testing needs. Our state-of-the-art facilities and expanded equipment base complement our scientific experience and high-quality capabilities for nose-only and whole-body exposure of rodents and large animals.
The range and quality of our inhalation capabilities are optimized through collaboration with our scientific expertise in areas such as general toxicology, developmental and reproductive toxicology, and metabolism to provide a comprehensive package of services.
Capabilities
Standard and Specialized Evaluations
- Rodent and non-rodent exposures for acute, subchronic and chronic toxicity studies
- Developmental toxicity
- Single and multi-generation reproduction assessments in rats
- Neurotoxicity assessments
- Cardiac sensitization
- Inhalation exposures for safety pharmacology studies, cardiovascular, respiratory and CNS
- Metabolism and toxicokinetic evaluations
- Cardiac and respiratory evaluations during or post-exposure
- Minute volume determinations for pharmaceutical dosimetry
Facilities and Equipment
- State-of-the-art multipurpose inhalation suites for whole-body or nose-only exposures
- Vivarium equipped to serve large animal exposure laboratory requirements
- Large inventory of H1000 and H2000 live-in whole-body exposure chambers
- Horizontal flow whole-body chambers (3.8 m³) for two-year studies in Sprague-Dawley rats; NYU-type whole-body chambers for rabbit developmental toxicity studies; also 125-L and 500-L chambers
- Modular directed-flow and conventional nose-only exposure systems and open-style restrainers to allow optimized, low-stress exposures
- Fully redundant systems including electric power, exhaust blowers, air compressors, vacuum pumps and effluent treatment
- Full range of generation equipment for gases, vapors, liquid aerosols and dusts; including nebulizers, MDI-systems and dry-powder methods for pharmaceuticals
- Concentration analysis by GC, HPLC, IR methods and gravimetric and real-time aerosol monitoring
- PC-based electronic monitoring and data acquisition of chamber environmental conditions and exposure concentrations
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